Abstract

Background:
Inflammation is a protective mechanism by which the body neutralizes and eradicates harmful agents at the site of injury and conditions tissue repair. Malacca plants contain active metabolites that are believed to be able to cure inflammation.

Aim:
This study aims to test the formula of ethanol extract cream of Malacca leaves 10%, 15%, and 20% with a negative control group (without treatment) and a positive control group (treated with betamethasone cream) and its anti-inflammatory activity through observation of edema of the feet of male mice induced by carrageenan.

Methods:
The physical stability of the cream formula was evaluated every week for 3 weeks at room temperature storage (±29ºC) by observing organoleptic, pH, viscosity, adhesiveness, and spreadability. Furthermore, an in vivo test consisting of 5 treatments and 5 repetitions using the mouse hind paw edema method. The volume of edema was measured using a plestimometer 30 min after carrageenan administration and every day for 4 days of treatment.

Results:
The results of the study showed the most significant decrease in edema volume using 10% (F1) Malacca cream. Differential leukocyte counts showed that the percentage of eosinophils in group K1 was the highest and significantly different (P

Key words: Malacca leaf ethanol extract; Inflammation; Leukocyte differential; Plethysmometer; Phyllanthus emblica.