Abstract

Objective: To investigate the relationship between quantitative computed tomography (QCT) parameters and clinical phenotypes in patients with stable chronic obstructive pulmonary disease COPD.
Methodology: This cross-sectional study included 60 patients clinically diagnosed with COPD. Demographic and clinical characteristics such as age, sex, smoking status, and body mass index (BMI) were recorded. Spirometry measurements, particularly forced expiratory volume in one second (FEV1), modified Medical Research Council (mMRC) dyspnea assessment, and six-minute walk distance (6MWD) were noted to evaluate lung function. Chest CT scans were obtained in all patients, and QCT analysis was performed to obtain the emphysema index, percent air trapping, airway wall thickness, and mean lung density. The Pearson correlation and linear regression analyses were performed via SPSS version 26.
Results: The average age was 65.3±9.4 years, and 70% of participants were male. The mean emphysema index was 32.4%, and air trapping was 29.1%. The emphysema index had a significant negative correlation with FEV1 (r = -0.58, p

Key words: Pulmonary disease, chronic obstructive, tomography, emphysema, airway obstruction.