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Effect of Curcumin and Angiotensin II Receptor Antagonist on Insulin Sensitivity and on Inflammation in Induced Diabetic Rats

Mohamed A Nassar, Ossama A Mansour, Gamil M Abd-Allah, Adel F Kholy.

Objective: In this study, we aimed to discuss the effect of Curcumin and/or Irbesartan on diabetic complications in induced diabetic rats.
Material and Methods: Diabetic rats induced by intraperitoneal injection of 45mg/kg dose of Streptozotocin (STZ) in adult rats. Rats were divided into six groups of ten rats on each. Serum glucose, creatinine, and urea were estimated using a colorimetric method. Serum insulin and serum and kidney homogenate interleukin 6 (IL6) were measured using ELISA technique. While paraffin embedded kidney and pancreas specimens were performed for histopathological examination. While Homeostasis model assessment of insulin resistance (HOMA-IR)was calculated.
Results: curcumin and/or irbesartan reduce the degradation of kidneys and pancreatic tissues as indicated in both histopathology and tissue IL-6. They improve the weight loss and insulin resistance. Also, they lower circulating level of IL-6, serum creatinine, and urea. Diabetic rats received the medications show significantly better insulin and glucose levels as compared to STZ group.
Conclusion: Chronic administration of curcumin and/or irbesartan for diabetic rats decreased serum glucose and HOMA-IR and lowered the increased serum levels of pro-inflammatory cytokines. Using such combination could be beneficial in diabetic managements especially if diabetes accompanied with hypertension.

Key words: Insulin resistance; Nephropathy; Inflammation; Diabetes Mellitus.

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