Aim: The present study was undertaken to evaluate the cardioprotective effect of alcoholic leaf extract of Mangifera indica L. against cardiac stress caused by doxorubicin.
Methods: Rats were treated with 100 mg/kg of M. indica leaf extract (MILE) in alone and interactive groups for 21 days. Apart from normal and MILE control groups, all the groups were subjected to doxorubicin (15 mg/kg, i.p.) toxicity for 21 days and effects of different treatments were analysed by changes in serum biomarkers, tissue antioxidant levels, electrocardiographic parameters, lipid profile and histopathological evaluation.
Results: MILE treated group showed decrease in serum biomarker enzyme levels and increase in tissue antioxidants levels. Compared to doxorubicin control group, MILE treated animals showed improvement in lipid profile, electrocardiographic parameters, histological score and mortality.
Conclusion: The present findings clearly suggest the protective role of alcoholic leaf extract of M. indica against oxidative stress induced by doxorubicin.
Key words: Chemotherapy adverse effects, oxidative stress, anthracycline cardiotoxicity, cardioprotection, rats