Ethanolic and aqueous extracts prepared from leaves of Coscinium fenestratum were evaluated for hepatotoxicity in cockerels. Acetaminophen was given @ 500 mg/kg b wt orally to induce hepatocellular damage. Ethanolic extract of C fenestratum @ 60 mg/kg b wt helped in restoration of Hb, PCV, TEC, TLC and lymphocytes and heterophils as well as total protein, albumin and globulin, glucose, cholesterol, bilirubin and activity of AST, ALT, ALP and LDH. Liver sections of treated animals clearly showed normal hepatic cells and central vein thereby confirming hepatoprotective activity. Phytochemical analysis of ethanolic extract showed presence of alkaloids, coumarin, flavonoids, glycosides, resins, sterol, tannin and triterpenes.
Key words: Cockerels, Hepatotoxicity, Coscinium fenestratum, Phytochemial analysis
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