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Kikuchi-Fujimoto disease: case report and review

Irami Araujo-Filho, Artur Dantas Freire, Irami Araújo-Neto, Carolina Chianca Dourado Lemos, Letícia Araújo Costa Uchôa, Amália Cínthia Meneses Rêgo, Marco Antônio Botelho Soares, José Francisco Correia-Neto, Carlos André Nunes Jatobá, Ana Maria de Oliveira Ramos.

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OBJECTIVE: The development of associated febrile to lymphadenomegaly leads to several diagnostic hypotheses, among them the Kikushi-Fujimoto disease.
METHOD: This review was set up by searching PubMed/Medline, Web of Science and Scopus database using the following key words: “Kikushi disease”, “Kikuchi-Fujimoto disease”, “histiocytic necrotizing”, “lymphadenitis”, “lymphadenopathy”.
RESULTS: We report a case in a young patient with a fever associated with the emergence of adenomegalies and weight loss in two months, associated with hepatosplenomegaly. In laboratory tests showed anemia with erythrocyte sedimentation rate (ESH) and lactate dehydrogenase (LDH) test elevated, widened mediastinum, with bilateral pleural effusion.
CONCLUSION: Excisional biopsy of supraclavicular lymph node showed Kikuchi-Fujimoto disease on microscopic examination. After histopathological confirmation, were other causes of febrile adenomegalias apart, starting dose corticosteroid immunosuppressive therapy.

Key words: Kikushi disease, Kikuchi-Fujimoto disease, histiocytic necrotizing lymphadenitis, lymphadenopathy

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