Home|Journals|Articles by Year

Directory for Medical Articles

Original Article

J App Pharm Sci. 2017; 7(11): 155-158

Spectrophotometric Determination of pKa and Log P of Risperidone

Sunil Kumar Dubey, Gautam Singhvi, Abhay Tyagi, Himanshu Agarwal, K. V. Krishna.


Objective: The spectrophotometric determination of pKa and Log P of Risperidone.
Materials and Methods: From the perspective of dosage form design and pharmaceutical analysis, the dissociation constant and partition coefficient are the most important physicochemical properties of a drug which need to be determined. The pKa determination of Risperidone was carried out using a simple UV–Visible spectrophotometric method and Log P was estimated using shake flask method followed by UV analysis.
Results and Conclusion: This study reports the experimental value of pKa and log P for Risperidone, an anti-psychotic drug, for the first time. The pKa value of Risperidone was found to be 8.62 and log P of Risperidone was estimated to be 3.50.

Key words: Anti-psychotic, Dissociation constant, Partition coefficient, Validation

Full-text options

Share this Article

Online Article Submission
• ejmanager.com

Review(er)s Central
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.