Home|Journals|Articles by Year|Audio Abstracts

Original Research

Comparative evaluation of different doses of intravenous dexmedetomidine during laparoscopic cholecystectomy under general anesthesia

Pooja Singh, Avtar Singh Yadav, Sudhakar Dwivedi, Subhash K Agrawal.


Background: Laparoscopy induces hemodynamic changes that lead to increased systemic vascular resistance, mean arterial pressure, heart rate, reduction in stroke volume, and cardiac output. Dexmedetomidine is a highly selective, potent, and specific alpha-2 agonist. It attenuates the hemodynamic changes associated with tracheal intubation, reduces plasma catecholamine concentration during anesthesia, and decreases perioperative requirements of inhaled anesthetics.

Objectives: This study attempts to compare the effects of two different doses of dexmedetomidine in maintaining perioperative hemodynamic parameters during laparoscopic cholecystectomy.

Materials and Methods: A total of 90 patients were randomly allocated to three groups, Group A (placebo), Group B (dexmedetomidine 0.5 μg/kg body weight), and Group C (dexmedetomidine 1 μg/kg body weight) of 30 patients each, undergoing elective laparoscopic cholecystectomy, under general anesthesia. The patients received preloaded study drug, 15 min before induction. The hemodynamic parameters were recorded before premedication, before induction, 1 min after intubation, 5 min after intubation before insufflation of CO2, after insufflation of CO2 at 1, 5, 10, 20, 30, 45, and 60 min, after release of CO2, at 1 and 10 min after extubation.

Results: The three groups were comparable for age, sex, weight as well as duration of surgery. Both doses maintained hemodynamic
stability during laparoscopic cholecystectomy. However, lesser sedation was seen in the Group B as compared to Group C.

Conclusion: Both doses of dexmedetomidine at doses were superior to placebo in terms of hamodynamic stability. Lesser sedation was seen with the 0.5 μg/kg body weight compared to dexmedetomidine 1 μg/kg body weight.

Key words: Dexmedetomidine; Pneumoperitoneum; Hemodynamic; Cholecystectomy

Full-text options

Share this Article

Online Article Submission
• ejmanager.com

ejPort - eJManager.com
Refer & Earn
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under Creative Commons Attribution 4.0 International License (CC BY), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.