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Evaluation of Sub-acute Exposure of Bifenthrin on Oxidative Profile of Bubalus bubalis

Rajdeep Kaur, Kamalpreet Kaur Gill, Prashant Sudamrao Daundkar, Simerjot Singh.


Abstract

Bifenthrin is a type-I pyrethroid with eight stereoisomers; the cis-isomer being the active moiety. The present study investigated the oxidative stress inducing potential of bifenthrin in eight male buffalo calves. Group I, served as control whereas group II animals were orally administered bifenthrin @ 5.0 mg/kg/day for 21 days. Bifenthrin treated animals showed significantly increased lipid peroxidation, evidenced by increased blood malondialdehyde levels from 17th day onwards, with maximum increase of 54.3%. Blood glutathione levels were decreased significantly (16.5%) by the last day of treatment. There was significant increase in the activity of superoxide dismutase on and after 17th day (96.5%) of administration. Similar alterations were observed in the activity of glutathione peroxidase with maximum incline of 28.8% on 21st day. However, no significant change was evidenced in catalase activity. The present investigation suggests that bifenthrin has a potential to induce oxidative stress on repeated sub-acute exposure in buffalo calves.

Key words: Bifenthrin, Lipid Peroxidation, Oxidative Stress, Buffalo Calves






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