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Pathophysiological Correlation between Diabetes Mellitus Type-II and Chronic Obstructive Pulmonary Diseases

Ahmad N. Bitar, Muhammad Ali Ghoto, Abdullah Dayo, Mudassar Iqbal Arain,Rabia Parveen.


INTRODUCTION: Diabetes Mellitus, a chronic disease is usually associated and linked to many other
conditions and complications. Chronic Obstructive Pulmonary Disease (COPD); a life threatening
progressive inflammatory lung disease associated with chronic bronchitis and emphysema; when
associated with Diabetes Mellitus generates a huge burden on patients quality of life as well as on health
care systems.
OBJECTIVE: Although link between DM and COPD is not scientifically established or confirmed yet,
however evidence suggest a pathophysiological correlation between both conditions might be present.
This study focuses upon impact of DM on the onset of COPD and to find if there is any evidence of the
suggested pathophysiological correlation.
METHODOLOGY: We retrospectively analyzed 120 cases of Chronic Obstructive Pulmonary Disease
(COPD), data collected from General Medical Units and Pulmonary Ward of Liaquat University Teaching
Hospital, Jamshoro / Hyderabad from January till June, 2016.
RESULTS: The majority of cases with COPD were male representing 81.6% of the sample population,
almost 90% of patients were smokers or ex-smokers, 42.50% of COPD patients were suffering from DM
and 76.47% were either non-compliant or had a very poor control over their blood glucose level. Blood
glucose levels of most of the patients was from 140 mg/dl to 500 mg/dl and 19.60% of patients reached
diabetic ketoacidosis (DKA) once at least.
CONCLUSION: DM increases the risk for occurrence of COPD and cause rapid decline in clinical state of
the patient. Unlike cardiovascular complication of diabetes in case of diabetic patients with COPD the
lower the BMI the higher the risk of mortality.

Key words: Diabetes Miletus (DM), Chronic Obstructive Pulmonary Diseases (COPD), Pathophysiological Correlation.

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