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A comparative study of event-related potential P300 between normal individuals and individuals with prediabetes

Satabdi Saha, Vijayadas Muradi, Preethi Bangalore Lakshmana Gowda, Pramila Kalra.


Background: Prediabetes is the early stage of Type 2 diabetes mellitus. Altered glucose metabolism, atherosclerosis, and inflammation of blood vessels are seen in prediabetes. This may lead to neurodegeneration and cognitive decline. Event-related potential P300 can easily detect cognitive decline before the appearance of any neurological manifestations.

Aims and Objective: The aim of this study is to assess and compare the P300 latencies in normal subjects and individuals with prediabetes.

Materials and Methods: The study included 25 individuals with prediabetes and 25 healthy controls between the age group of 20 and 50 years. After obtaining informed consent, the study subjects were evaluated by history, general physical, and systemic examination. Serum HbA1c level was estimated. P300 was recorded using the standard auditory oddball paradigm from the vertex (Fz, Cz, and Pz) in response to stimuli presented monaurally through head phones. The peak latencies of P300 of target stimuli were calculated.

Results: Mean P300 latency in normal individuals was 305.15 ms ± 27.80 and in individuals with prediabetes 383.98 ms ± 22.02 which is statistically significant (P ˂ 0.05).

Conclusion: Increase in P300 latencies indicates the existence of a cognitive decline in individuals with prediabetes compared to healthy individuals.

Key words: Event-related Potential P300; Prediabetes; Cognitive Function; Serum HbA1c

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