Home|Journals|Articles by Year Follow on Twitter

Directory for Medical Articles

Open Access

Original Research

Natl J Med Res. 2012; 2(3): 376-380

Comparison of Intermittent Bolus and Continuous Infusion Techniques for Administration of Atracurium in Renal Failure

Madhavi Potnis, Shishir Mehta, Deepak Mistry, Nalini Desai.

Introduction: Atracurium besylate is bisquaternary isoquinolinium compound, a potent non depolarizing muscle relaxant of intermediate duration. Its duration of action appears not to be prolonged in absence of normal renal function. Atracurium lacks cumulative effects and its shorter duration of action and rapid recovery from block suggest that Atracurium may be suitable for continuous intravenous infusion.
Objectives: the present study was planned to compare effect of intermittent and intravenous infusion of atracurium in kidney diseases.
Methods: Eighty patients scheduled for elective surgery were randomized into two groups: A and B. Their blood urea was > 80mg/dl, S.Creatinine >2mg%.Patients were assigned randomly to atracurium either as intermittent bolus(group A, n=40) or continuous infusion(group B, n=40). During induction phase each patient was given Inj. Propofol 1.5mg/kg I.V. and was paralysed with Inj.Atracurium 0.5mg/kg I.V. Various clinical parameters are monitored and compared.
Results: In group A, the average pulse rate was 87.59±8.57mins with 9.78 percentage of intraoperative changes in pulse. While in group B the average pulse rate was 92.45±5.71mins with 6.18 percentage of intraoperative changes in pulse P = 0.002. No significant change was seen in blood pressure fluctuation. There is no significant difference in recovery time in either groups ( A : 11.1±2.2 and B : 11.4±2.6 min). The average total intraoperative dosage of atracurium in group A was 22.46±7.9 mg and the average total intraoperative dosage of atracurium in group B was 15.44±5.69 mg. (P = 0.0001).
Conclusion: Intravenous continuous infusion is suitable alternative method of administration of atracurium in renal failure patients as it provides continuous adequate steady state of anaesthesia, stable haemodynamics and lesser intraoperative dosage requirement.

Key words: Atracurium, Renal Failure, Bolus, Infusion, Blood Pressure, Pulse Rate

Similar Articles

Application of atmospheric pressure glow discharge generated in contact with liquids for determination of chloride and bromide in water and juice samples by optical emission spectrometry.
Gorska M, Pohl P
Talanta. 2022; 237(): 122921

The DR1‑CSE/HS system inhibits renal fibrosis by downregulating the ERK1/2 signaling pathway in diabetic mice.
Li H, Sun F, Bai S, Chang G, Wu R, Wei Y, Wen X, Xi Y, Hao J, Zaid A
International journal of molecular medicine. 2022; 49(1):

Neutrophil-to-lymphocyte ratio in sporadic amyotrophic lateral sclerosis.
Wei QQ, Hou YB, Zhang LY, Ou RW, Cao B, Chen YP, Shang HF
Neural regeneration research. 2022; 17(4): 875-880

Radiofrequency thermocoagulation for the treatment of trigeminal neuralgia.
Wang Z, Wang Z, Li K, Su X, Du C, Tian Y
Experimental and therapeutic medicine. 2022; 23(1): 17

Blood stem cell PU.1 upregulation is a consequence of differentiation without fast autoregulation.
Ahmed N, Etzrodt M, Dettinger P, Kull T, Loeffler D, Hoppe PS, Chavez JS, Zhang Y, Camargo Ortega G, Hilsenbeck O, Nakajima H, Pietras EM, Schroeder T
The Journal of experimental medicine. 2022; 219(1):

Full-text options

Latest Statistics about COVID-19
• pubstat.org

Add your Article(s) to Indexes
• citeindex.org

Covid-19 Trends and Statistics
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright © ScopeMed® Information Services.

ScopeMed Web Sites