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Haemato-Biochemical Evaluation of Ketamine or Butorphanol as Analgesic in Xylazine and Propofol Anaesthesia in Canine Ovariohysterectomy

Kumari Chandrakala, Arvind Kumar Sharma, Laxmi Kumari, Raju Prasad, Kaushal Kumar Singh, Praveen Kumar.


The object of present study to evaluate the haematobiochemical profiles following administration of ketamine or butorphanol as preanaesthetic analgesic in xylazine -propofol anaesthesia elective ovariohysterectomy procedure. All dogs were divided randomly in to two groups of five animals in each and designed as Group I and Group II. Atropine sulphate was injected s/c @ 0.04 mg/kg b.wt. 5 min. prior to each treatment in the animals of both the groups. Group I, received xylazine @ 1 mg/kg bwt IM –Ketamin @ 3 mg/kg b.wt, IM whereas, animals group II were administered with xylazine @ 1 mg/kg b.wt. IM –Butorphanol @ 0.2 mg/kg b.wt, IM. Surgical anaesthesia was induced by administration of propofol “to effect” 15 min after preanaesthetics and maintenance of anaesthesia was carried out for 30 min (Maximum operative time to complete ovariohysterectomy procedure) with continuous rate infusion technique of propofol @ @ 0.3 mg/kg b.wt./min. Lymphocytopenia and relative neutrophilia was the consistent findings, where as other haematological parameters did not revealed any significant findings. The biochemical parameters (BUN, creatinine, ALT and AST) were non-significantly variables, whereas, hyperglycemia was the consitent findings at 1 hrs intervals in both the groups. Changes in total protein were transiently variables. In conclusion, A transient variables within physiological limits have been reported following ketamine or butorphanol as preanaesthetic analgesic in xylazine and propofol induced anaesthesia which further maintained with continuous rate infusion of propofol @0.3 mg/kg/min. Hence , these combination of anaesthesia was safely used in compromised animal.

Key words: Bitch, Butorphanol, Haemato-Biochemical Changes, Ketamine, Propofol, Ovariohysterectomy

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