Abstract

The aim of this work was to determine the acute toxicity of hydro-alcoholic extract of S. rhombifolia L. (EHASr), and its influence on general behavior, sleeping time induced by pentobarbital, intestinal transit migration and the effect on spontaneous contractile response of intestinal smooth muscles isolated from mice. Doses up to 3000.0 mg/kg p.o. and 1000.0 mg/kg i.p. of EHASr did not produce any toxic symptoms. Oral administration of 100.0 mg/kg of EHASr promotes statistically significant increase of charcoal marker migration (** p

Key words: Sida rhombifolia; Acute toxicity; Behavior; Intestinal transit; Intestinal smooth mucle.