OBJECTIVE: To evaluate with endoscopy the common causes of upper gastrointestinal
bleeding in patients presenting with hematemesis within 24 hours of admission.
DESIGN: A cross sectional observational study.
SETTING: Medical unit III, LUMHS Jamshoro.
DURATION: Six months from 1st Jul, 2014 - 31st Dec, 2014.
METHODS: One hundred cases of hematemesis were included in the study. Patients who
refused endoscopy and those on NSAIDs, anticoagulants & steroids were excluded from study.
Upper gastrointestinal endoscopy was performed within 24 hours of admission.
RESULTS: Out of 100 patients selected, 51 (51%) were males and 49 (49%) females. Majority of
patients were between 30-60 years with mean age of 43.97 years ±SD 7.8. Variceal bleed was
the most common cause n=54 (54%) followed by peptic ulcer disease (PUD) n=20 (20%).
Esophagitis was noted in ten (10%) patients, gastric erosions in nine (9%), tumors of upper
gastrointestinal tract in six (6%) and Mallory-Weiss tear was responsible in only one (1%) cases.
CONCLUSION: Variceal bleeding secondary to portal hypertension is the most frequent cause
of bleeding in upper gastrointestinal tract. Increased prevalence of hepatitis B virus (HBV) and
hepatitis C virus (HCV) in this part of the world has resulted in increased incidence of liver
cirrhosis and portal hypertension highlighting the importance of prevention of HBV and HCV.
Upper gastrointestinal bleeding, Varices, Peptic ulcer disease, Endoscopy,
Exploring the Alzheimer's disease neuroepigenome: recent advances and future trends.
Zhang H, Elefant F
Neural regeneration research. 2022; 17(2): 325-327
Growth differentiation factor 5: a neurotrophic factor with neuroprotective potential in Parkinson's disease.
Goulding SR, Anantha J, Collins LM, Sullivan AM, O'Keeffe GW
Neural regeneration research. 2022; 17(1): 38-44
Differentiating Human Pluripotent Stem Cells to Vascular Endothelial Cells for Regenerative Medicine, Tissue Engineering, and Disease Modeling.
Bertucci T, Kakarla S, Kim D, Dai G
Methods in molecular biology (Clifton, N.J.). 2022; 2375(): 1-12
Presenilin mutations and their impact on neuronal differentiation in Alzheimer's disease.
Hernandez-Sapiens MA, Reza-ZaldĂvar EE, MĂˇrquez-Aguirre AL, GĂłmez-Pinedo U, Matias-Guiu J, Cevallos RR, Mateos-DĂaz JC, SĂˇnchez-GonzĂˇlez VJ, Canales-Aguirre AA
Neural regeneration research. 2022; 17(1): 31-37
SYNGR4 and PLEKHB1 deregulation in motor neurons of amyotrophic lateral sclerosis models: potential contributions to pathobiology.
Marques RF, Duncan KE
Neural regeneration research. 2022; 17(2): 266-270