Abstract

Aim: This study investigated the diagnostic and prognostic potential of the Systemic Immune Inflammation Index (SII), Neutrophil Lymphocyte Ratio (NLR), and Platelet Lymphocyte Ratio (PLR) in cervical dysplasia, evaluating their correlation with disease presence and severity for potential clinical applications in risk assessment and patient management.
Materials and Methods: In this retrospective study, the values of SII, NLR, and PLR were analyzed using parameters obtained from the routine complete blood count of 215 patients whose cervical dysplasia grades were evaluated through colposcopic biopsy.
Results: HPV DNA types 16 and/or 18 were detected in 114 (53.0%) of 215 patients, while 101 (47.0%) tested positive for non-16/18 hr-HPV DNA types. No statistically significant difference was observed in WBC, neutrophil, platelet, lymphocyte, SII, NLR, and PLR values when comparing the chronic cervicitis, Low-Grade Squamous Intraepithelial Lesions (LSIL), and High-Grade Squamous Intraepithelial Lesions (HSIL) groups (p>0.05). However, logistic regression analysis for HSIL risk identified lymphocyte count (OR=0.998) and PLR (OR=0.975) as significant predictors, where a one-unit increase in each was associated with a 0.2% and 2.5% decrease in the odds of HSIL, respectively.
Conclusion: This study revealed no significant correlation between SII, NLR, and PLR values in diagnosing or grading cervical dysplasia’s presence or severity, suggesting limited utility for these systemic inflammatory markers alone as diagnostic or prognostic tools. Further validation through larger prospective studies is warranted to elucidate the role of these markers more comprehensively.

Key words: systemic immune inflammation index; platelet-lymphocyte ratio, neutrophil-lymphocyte ratio; complete blood count; cervical intraepitelial neoplasia