Home|Journals|Articles by Year

Directory for Medical Articles
 

Original Article

AJVS. 2016; 51(2): 386-392


Impact of the Neonicotinoid Insecticide, Thiamethoxam, on Some Reproductive Parameters in Adult Male Rabbits

Ahmed R. El-Sawasany, Osama S. El Okle, Omnia I. El Euony, Ashraf M. Nazem.


Abstract

Thiamethoxam (TMX) is one of new class neonicotinoid insecticides currently available in the Egyptian pesticide markets. The current study was designed to investigate the toxic effect of TMX on reproductive system in adult male rabbits. For this purpose, sixteen adult male Chinchilla rabbits were divided into two equal groups. Animals in the first group were treated orally with TMX at dose of 250 mg/kg b.wt for 90 days. The second group was served as control. Hormonal analysis revealed that, TMX induced a significant elevation in the serum testosterone level, while the concentrations of FSH and LH hormones did not exhibit any alterations between treated and control groups. Obtained results also showed that TMX treatment did not cause significant sperm DNA fragmentation, but caused marked alteration in sperm parameters (e.g. concentration, motility and morphology). Degeneration and necrosis of the spermatogenic cells in addition to intertubular edema and vacuolations were the major observed histopathological lesions in the testis of intoxicated animals. In conclusion, administration of TMX for 90 days in male rabbits induced a noticeable adverse effect on the testicular function and structure without the impairment of gonadotropins secretion.

Key words: Gonadotropins; Rabbits; Sperm DNA; Sperm parameters; Testis; Thiamethoxam






Full-text options


Share this Article



Online Article Submission
• ejmanager.com
• ojshosting.net







Do you want to use OJS for your journal ?
work with an experienced partner
www.OJSHosting.net

eJManager.com
Review(er)s Central
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.