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Original Article

J App Pharm Sci. 2017; 7(4): 168-173

Phytochemical study and anti-inflammatory effect of Psychotria stenocalyx (Rubiaceae)

Gustavo Silva Queiroz, Ana Beatriz Gobbo Luz, Marcus Vinícius Pereira dos Santos Nascimento, Sergio Scherrer Thomasi, Antonio Gilberto Ferreira, Eduardo Monguilhott Dalmarco, Ines Maria Costa Brighente.


In this study, an in vivo anti-inflammatory assay was conducted on Psychotria stenocalyx ethanol extract of leaves, evaluating this effect on cell migration and exudate formation in a murine carrageenan-induced model of pleurisy. The extract showed the optimum dose, at 400 mg/kg, inhibiting cellular and vascular parameters: total leucocytes due to polymorphonuclear migration and exudate formation (p < 0.01). A phytochemical study was conducted using the hyphenated techniques HPLC-DAD-SPE/NMR and HPLC-DAD-ESI-TOF-HRMS, in which seven monoterpene indole alkaloids were identified: lyaloside 1, (E)-O-(6′)-cinnamoyl-4”-hydroxy-3”,5”-dimethoxy-lyaloside 2, strictosamide 3, pauridianthoside 4, vallesiachotamine lactone 5, E-vallesiachotamine 6 and Z-vallesiachotamine 7, in the alkaloid fraction, obtained by an acid-base extraction on P. stenocalyx crude extract. This is the first study developed with this species.

Key words: Psychotria stenocalyx anti-inflammatory monoterpene indole alkaloids HPLC-DAD-SPE/NMR

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