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Ann Med Res. 2017; 24(3): 261-264

The effect of sevoflurane anesthesia on the corneal endothel

Nihat Polat, Ahmet Selim Ozkan, Abuzer Gunduz, Pamuk Betul Ulucan, Cemil Colak.

Aim: To evaluate the mean changes in corneal endothelial cells in eyes that operated under sevoflurane general anesthesia.
Material and Methods: 32 eyes of 32 patients who had extraocular surgery under general anesthesia included in this prospective
study. Cell density (CD), Coefficient of Variation (CV) and Hexagonality rate (Hex) specular microscopy results at before surgery and
1 week and 1 month after surgery were analyzed.
Results: The mean age of the patients was 15 10 (min 4- max 36). The mean operation time of the patients was 90 15 minutes.
The mean preoperative CD value of the study subjects was 309715 cell/mm2. The mean postoperative CD value was 3119194
cell/mm2 at the 1.week and 3120207 cell/mm2 at the 1.month (p=0.678). The mean preoperative CV was 0.270.4 while the
postoperative 1. week value was 0.270.4, and the postoperative 1st month value was 0.270.5 (p=0.319). The mean preoperative
Hex value of the study subjects was 5310%. The mean postoperative Hex value was 5411% at the 1.week and 5510% at the
1.month (p=0.992). No significant difference was present between the periods in terms of CD, CV and Hex.
Conclusion: There is no change in the corneal endothel in patients who suffered general anesthesia with sevoflurane.

Key words: General Anesthesia; Corneal Endothel; Sevoflurane.

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