Abstract

Objective: To evaluate the abnormal lipid profile and its correlation with end-stage liver disease patients.
Methodology: This cross-sectional study was conducted in the Department of Biochemistry, PUMHSW and the Department of Community Medicine, PMC Hospital, Nawabshah, from July to December 2023. It included 200 CLD patients aged≥20 years of both genders. To assess dyslipidemia patterns, lipid profiles and routine tests were conducted.
Results: Out of 200 patients, 120 (60.0%) were male and 80(40.0%) were female. The mean serum cholesterol level was 165.04±59.63 mg/dl, mean serum triglyceride level was 208.86±137.13 mg/dl, mean serum LDL level was 89.68±19.15 mg/dl, and mean serum HDL level was 40.98±11.19 mg/dl. Severity of disease showed that there were 33 participants in class A, 119 in class B and 48 in class C according to Child Pugh classification. There was statistically significant association between CLD and total cholesterol (p=0.025), and triglycerides (p=0.001). No significant association was observed between CLD and LDL / HDL.
Conclusion: There was a statistically significant association between end-stage liver disease and lipid parameters. Treatment strategy should be focused on complications related to a deranged lipid profile in hospitalized patients with CLD.

Key words: Chronic liver disease, dyslipidemia, lipid parameters.