BACKGROUND: Cadmium is a ubiquitous heavy metal and a toxic pollutant in the biosphere which has been implicated as one of the factors responsible for cardiovascular risk and mortalities. This work was therefore conducted to ascertain the effects of omega-3 and/or quercetin on cadmium-induced cardio-toxicity in rats.
MATERIALS AND METHODS: Forty two (42) Wistar rats were assigned into 7 groups of 6 rats each and fed for 4 weeks with normal rat feed and drinking water. The treatment groups took either of cadmium chloride, omega-3 fatty acid and/or quercetin. The sham control groups 1 and 2 took olive oil (1mL/kg body wt. o.p) and DMSO (1mL/kg body wt. o.p) respectively. Serum was obtained from the blood samples for measurement of the various cardiac function indices. The heart was also harvested for histological studies. RESULTS: Results obtained showed that the cardiac function parameters in the sham control groups were not significantly different from normal control. The LD50 for cadmium was 3.90mg/kg bw. Serum troponin, myoglobin, creatinine kinase and C-reactive peptide increased significantly (p
Key words: Cadmium, cardio-toxicity, Omega-3 fatty acid, quercetin, cardio-biomarkers
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