Abstract

Aim: Interleukin (IL)-32, a recently discovered proinflammatory cytokine, is demonstrated in several infectious diseases. The goal
of this study is to investigate the levels of IL-6, IL-10 and IL-32 in gingival tissue and serum of rats with experimental periodontitis.
Material and Methods: Experimental periodontitis was induced by placing a silk ligature around the cervix of both sides of mandibular
first molars in each male rat except for control group (Group 1). Thirty male Wistar albino rats were randomly divided into three
groups of ten animals each as experimental periodontitis groups (Group 2, ligated for seven days; Group 3, ligated for fourteen days)
and periodontally healthy control group (Group 1). At the end of experimental period, rats were sacrificed, and histomorphometric
analyses were performed on the mandibles. IL-32, IL-10 and IL-6 levels were measured in gingival tissue and serum samples by
ELISA.
Results: Alveolar bone and attachment loss were statistically higher in all experimental groups than those in control group (P

Key words: Interleukin-32; Experimental Periodontitis; Gingiva; Serum.