Home|Journals Follow on Twitter| Subscribe to List

Directory for Medical Articles
 

Open Access

Original Article



APPLICATION OF SIMPLEX CENTROID DESIGN IN FORMULATION AND OPTIMIZATION OF FLOATING MATRIX TABLETS OF METFORMIN

Meenakshi Bhavesh patel, Farhatjahan Shaikh, Vandana Patel, Naazneen Imtiaz Surti.

Abstract
ABSTRACT

The purpose of this research work was to develop the buoyant matrices of metformin by the direct compression method using mixture design as an optimization technique. The simplex Centroid design was practiced as an optimization technique by modifying the quantity of three elements simultaneously and holding back their total concentration constant.
Method: The amounts of HPMC K15M (X1), kappa-Carrageenan (X2) and sodium bicarbonate (X3) were used as the independent variables while floating lag time (Y1), % drug released after 1 hour(Y2) and time required for 90% (t90) were taken as the response variables. As per the simplex centroid design total 14 formulations were formulated. Matrices were evaluated for physical parameters, in-vitro buoyancy, swelling ability and adhesion retention period.
Results: The results of response variables were statistically evaluated using design expert software. Formulation M-SCD 7 was found to be the optimum having good floating lag time and also matching the desirability criteria for drug release. The formulation also gave reasonably high adhesion retention period and swelling index desirable for securing the retention of formulation in the abdomen.
Conclusion: It was concluded that the mixture of kappa carrageenan and HPMC K 15 M increases the flexibility in the release pattern of the drug. This study establishes the use of simplex centroid design in the development of floating matrix tablets with minimum experimentation.

Key words: Simple centroid design, mixture design, metformin, gastro retentive, HPMC, carrageenan



Share this Article


Advertisement
American Journal of Preventive Medicine and Public Health

SUBMIT YOUR ARTICLE NOW


ScopeMed.com
BiblioMed Home
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.