Home|Journals|Articles by Year Follow on Twitter| Subscribe to List

Directory for Medical Articles

Open Access

Original Article

J App Pharm Sci. 2017; 7(3): 135-140

Comparative study on the phenolic content, antioxidant properties and HPLC fingerprinting of the leaf extracts of Clerodendrum volubile P. Beauv

Olorunfemi R. Molehin, Omotade I. Oloyede, Aline A. Boligon.

The present study aimed to investigate the phenolic contents and antioxidant properties of the various leaf extracts (methanol, ethanol, ethyl acetate) of Clerodendrum volubile. In vitro scavenging activities of the extracts were assessed against 1,1-diphenyl-2 picrylhydrazyl (DPPH), 2,2- azinobis (3-ethylbenzo-thiazoline- 6-sulfonate (ABTS) radical scavenging ability (ABTS) radicals. The reducing power ability and high-performance liquid chromatography-diode-array detector (HPLCDAD) of the extracts was also determined. The methanol extract had the highest reducing power, DPPH and ABTS radicals scavenging activities, followed by ethanol and ethyl acetate extracts. The HPLC-DAD results revealed the presence of both phenolic acids (caffeic acid, gallic acid) and flavonoids (catechin, quercetin, rutin, quercitrin, kaempferol, luteolin, apigenin) as its major bioactive polyphenolics. The difference in scavenging potential of the extracts may be due to variation in the phytoconstituents extracted using various solvents. The result suggests that the methanol leaf extract of Clerodendrum volubile could serve as a potential source of antioxidants and can be explored as a therapeutic agent in free radical induced diseases.

Key words: Clerodendrum volubile; Antioxidant; Scavenging activity, HPLC-DAD

Full-text options

Full-text Article



BiblioMed Home
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.