Pharmacogenetics is a field of medicine that combines genetics and pharmacology, primarily focusing on the identification of genetic variants to help predict drug response and possible adverse reactions. As both response rates and the occurrence of side effects vary between patients, genetic testing can help explain the reason for these differences. Pharmacogenetic testing helps personalize treatment with the objective of enhancing drug efficacy, safety, and outcomes. In this review, we focused on the impact of cytochrome P450 variants on treating hypercholesterolemia and type 2 diabetes. Optimizing cholesterol management and diabetes treatment can lower cardiovascular risk and mortality, which poses a huge threat to today’s world due to the increasing popularity of a sedentary lifestyle and the growing incidence of these metabolic diseases.
Key words: hypercholesterolemia, diabetes, pharmacogenetics, CYP enzymes, ARDs
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