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Original Article

PAFMJ. 2016; 66(6): 814-818


THE IL-6 DEPENDENT EFFECT OF ORAL WARFARIN IN HEART VALVE REPLACEMENT PATIENTS BY MEASURING INTERACTING CLINICAL AND DEMOGRAPHIC VARIABLES

Huma Shafiq, Imran Asghar, Amir Rashid, Asifa Majeed, Suhail Razak.

Abstract
Objective: To examine an inflammatory effect of warfarin and comparing with IL-6 levels along with different demographic and clinical variables.
Study Design: Qusai experimental study.
Place and Duration of Study: Center of Research in Experimental and Applied Medicine (CREAM), Army Medical College/National University of Sciences and Technology, Islamabad from Oct 2013 to Oct 2015.
Material and Methods: The study design was Quasi Experimental study. Samples were collected by Non-probability convenience sampling. Total 76 patients were included according to warfarin dose response in warfarin therapy patients, i.e. 32(42%) were taking 10mg/day of warfarin dose. Patientís demographic and clinical variables were noted i.e. age, gender, BMI, duration of therapy, INR history, hepatic, gastrointestinal and diabetic complications. Human IL-6 ELISA assay was performed.
Results: The statistically significant difference was found between age groups (in years) and different levels of warfarin dose (p=0.046) along with IL-6 production. There is a negative correlation between warfarin dose and age group i.e. as age increases, the dose of warfarin decreases. Among the inter and intra-patient variability age and serum IL-6 levels were found to be statistically significant with warfarin dose response. BMI and warfarin dose were found to be weak positively correlated.
Conclusion: A marked immunomodulatory response of warfarin was noted by measuring IL-6 levels. IL-6 levels retained a significant association with warfarin dose.

Key words: Warfarin, International Normalized Ratio (INR), IL-6, Clinical survey.



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