Abstract

Gout represents a significant health challenge in Vietnam, where conventional urate-lowering drugs are frequently complemented with traditional herbal medicine. The clinical presentation and progression of Gout vary based on the patient’s physiology, comorbidities, and treatment response. Despite breakthroughs in modern healthcare, Gout management remains suboptimal worldwide, contributing to increased morbidity, disability, and reduced quality of life. This review synthesizes recent evidence on traditional Vietnamese medicine (TVM) formulations used in both experimental models and clinical settings for the treatment of Gout. We examine the pathophysiology of Gout from the perspective of Bi pattern disorders, analyze the clinical applications of single herbs and compound formulations, and elucidate their pharmacological mechanisms and bioactive constituents. This research compiled scholarly articles focused on the research of anti-Gouty arthritis conducted from 2010 to 2024. Data were collected from diverse academic journals and online resources, including PubMed, Web of Science, Elsevier, and Google Scholar. The process of sourcing and reviewing literature was based on search terms such as “acute Gouty arthritis and Vietnam herbal medicine,” “acute arthritis and treatment,” and “acute arthritis herbal extract.” Our analysis reveals that Vietnamese herbal medicines demonstrate multiple therapeutic actions, including xanthine oxidase inhibition, anti-inflammatory effects, antioxidant properties, and enhanced uric acid excretion. The review highlights both single herbs (such as Caesalpinia sappan, Blumea balsamifera, and Gnetum montanum) and complex formulations (including Hoa U Hoan and Chi Thong Nhu Than Thang) with documented efficacy. While promising, current research has limitations in terms of standardization, sample size, and mechanistic understanding. This comprehensive review provides a foundation for integrating TVM into modern Gout management and developing novel therapeutic approaches with enhanced efficacy and reduced adverse effects.

Key words: Keywords:Gout; arthritis; traditional Vietnamese remedies, Bi pattern