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Biomed Res Ther. 2016; 3(11): 973-984

Association of a single nucleotide polymorphism at 6q25.1, rs2046210 with breast cancer risk among Vietnamese population

Nguyen Thi Tuyet Lan, Bui Thanh Nhan, Nguyen Thi Ngoc Thanh, Nguyen Dien Thanh Giang, Phan Ngo Hoang, Tran Van Thiep, Nguyen Thi Hue.

Introduction: This study aims to confirm the association between SNP rs2046210 and breast cancer in the Vietnamese population.

Methods: A case/control study has been performed with the sample size of 300 cases and 325 controls. High Resolution Melting method is optimised for SNP genotyping. Statistic logistic regression analysis was used along with dominant and recessive analysis to analyse the association between alleles and genotypes of the selected SNP and breast cancer risk.

Results: With the selection population and the optimal HRM method, genotyping resulted in precise data for association analysis as the HWE test showed the distribution of genotypes in the population is in equilibrium (p > 0.05). The logistic regression association analysis showed SNP rs2046210 strongly associated with breast cancer risk in both allelic (p = 0.0015) and genotypic (p = 0.0064) analysis. The risk allele A, like other previous studies, strongly associated with increasing the risk of breast cancer up to 1.425 folds (OR [95%CI] = 1.425 [1.143- 1.777], p = 0.0015). However, it has shown the recessive effect in the additive analysis. Genotype AA showed stronger effect on the risk of breast cancer while the heterozygous AG genotypes showed weaker effect. Due to the small sample size, statistical power of this study is not high as expected (58.67%). But this case/control study confirms the association between SNP rs2046210 and the risk of breast cancer in the Vietnamese population.

Conclusion: SNP rs2046210 is associated with breast cancer risk in the Vietnamese population. The risk allele A plays a role in increasing the risk of breast cancer in Vietnamese women.

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