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Review Article

SRP. 2020; 11(12): 1889-1895


Synthesis some of thiazolidinoneand tetrazole compounds derived from acriflavine and evaluation of their antimicrobial, antifungal and antioxidant activity

Malath Khalaf Rasheed, Diana AbdAlkreem.Al-Rifaie.

Abstract
Some thiazolidinone and tetrazole compounds (7-12),(13-18) were derived from the acriflavine by the synthesis of Schiff bases as intermediate compounds (1-6). Schiff bases compounds were synthesized by reaction the acriflavine with different aldehydes by using microwave method. Thiazolidinone and tetrazole compounds wereprepared by the cyclization of Schiff bases with thioaceticacid to obtain of thiazolidinone compounds (7-12) and with sodium azide to products of tetrazole compounds (13-18). IR, 1H-NMR, and Mass Spectra data have confirmed the structures of synthesized compounds. The synthesized compounds have been screened for their antimicrobial, antifungal, and antioxidant activity.

Key words: Acriflavine, thiazolidinone, tetrazole, antimicrobial, antifungal,



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