Carbohydrate is a natural constituent of all living beings like: bacteria, fungi, plants and placental
mammals’ milk, in which oligosaccharide are the main constituents. The milk is a rich source of
oligosaccharides with different novel oligosaccharides depending on the nature of the origin of mammals the
milk belongs. One of the most important roles for milk is to support the immune system of a newborn, and
provide bioactive molecules that allow the gastrointestinal tract of the new born to mature, this maturation play
important role in development of a healthy balance of microflora. Goat milk oligosaccharides have antiinflammatory effects. It is valuable for intestinal protection and fix after the harm brought about by DSS
(Dextron sodium sulphate)-induced colitis and their implication in human intestinal inflammation. Bison milk
oligosaccharides have resistivity against parasitic diseases. Donkey milk oligosaccharides stimulate non-specific
and specific immunological resistance. The cows’ milk oligosaccharides decrease the addition of enterotoxic
Escherichia coli strains of the calf. Keeping all biological activity of different milk in mind, Gaddi sheep's milk
was collected and processed by Modified method of Kobata and Ginsburg and afterward purified by Sephadex
G-25 Gel column. The homogeneity was affirmed by reverse phase high performance chromatography. The
acetylation of oligosaccharides mixture followed by the silica gel chromatography led to isolation of novel
oligosaccharides. The contagious action of Gaddi sheep's milk oligosaccharides was explored against three types
of Trichoderma, to be specific T. polysporum, T. flavofuscum and T. longibrachiatum, based on their
importance as human pathogens. All samples of milk oligosaccharide exhibited fungal activity against these
Milk Oligosaccharides, Trichoderma, Microbial Activity, NMR
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