Home|Journals|Articles by Year|Audio Abstracts
 

Original Research



Ability of Urtica chamaedroydes pursh to restore hematopoiesis in anemic pregnant mice

Rodolfo Velasco Lezama, Martha Fregoso Padilla, José Luis Flores Sáenz, Jorge Carrillo Santana, Sara Beatriz Herrera Solis, Elisa Vega Avila, Eduardo Barrera Escorcia.




Abstract

Aim/Background: Iron-deficiency anemia (IDA) is associated during pregnancy with increased mortality and morbidity maternal-infantile rate, malformations and fetal or neonatal death. To avoid the death or malformations of fetuses the Indian communities use Urtica chamaedroydes. The purpose of this study was to investigate the ability of the decoction of U .chamaedroydes (chichicastle) to restore the hematopoiesis in pregnant mice and to avoid malformations in fetuses.
Methods: Forty female mice CD1, 8–12 weeks were distributed in groups A, B and C with ten animals each. Anemia was induced in groups A, B and C by courts in tail twice a week during 15 days. Hematological determinations were performed on days 0, 15 and 34. On day 15 the pregnancy was induced in all anemic mice and the healthy control group (D). During the gestation, groups A and D did not receive treatment. Group B was treated with a decoction of Urtica chamaedroydes (4 g/L) as drinking water and Group C with two sc administrations of 200 mg/kg of FeSO4. On day 34 all groups were sacrificed.
Results: Groups treated with the decoction of U. chamaedroydes or FeSO4 recovered the normal level of erythrocytes and platelets, none statistically significant differences were found between the concentration of these elements among days 0 and 34 within the same group. Neither the decoction nor FeSO4 allowed recover the normal level of leukocytes. From the total fetuses, malformations were observed in 80 20, 5, 10 % of Groups A, B, D and C, respectively.
Conclusion: These results could support the traditional medicinal use of this plant in the treatment of the anemia and to prevent malformations.

Key words: Iron-deficiency anemia, Urtica chamaedroydes, Hematopoiesis.






Full-text options


Share this Article


Online Article Submission
• ejmanager.com




ejPort - eJManager.com
Refer & Earn
JournalList
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under Creative Commons Attribution 4.0 International License (CC BY), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.