OBJECTIVE: To evaluate the relationship between body mass index and reproductive hormones (FSH and LH) in infertile females.
STUDY DESIGN: Analytical Case Control study.
PLACE AND DURATION OF STUDY: Department of Physiology, Islamic International Medical College, Rawalpindi from 1st January 2013 to 31st December 2013.
METHODOLOGY: One Hundred and fifty (150) normal, overweight and obese infertile females aged 20 to 39 years, who had ovarian and tubal blockage and causes of infertility, were included in the study. They were sub-divided into three groups in accordance with World Health Organization (WHO) classification for Body Mass Index (BMI). Each group comprised of fifty (50) subjects. After detailed history and general physical examination, samples of blood were drawn on day three (3) of the menstrual cycle in the subjects for the assay of serum reproductive hormone levels.
RESULTS: Effect of increased BMI on serum hormone levels in normal, overweight and obese groups are observed in table below. Serum FSH was highly statistically significant (p=0.001**). Serum LH was statistically significant (p=0.048*). Analysis of Variance test revealed that serum FSH and LH levels were significantly associated with BMI in all the three groups.
CONCLUSION: Increased BMI leads to significant negative association with reproductive hormones (FSH and LH) in infertile women.
Obesity, Reproductive Hormones, Infertility, Body Mass Index