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Original Article

Fibrinolysis parameters in the acute and post ischemic stroke patients

Tetiana Katrii, Viktoria shandyuk, Natalia Raksha, Tetiana Halenova, Olexiy Shershnov, Volodymyr Melnyk, Olexiy Savchuk.


Analysis of fibrinolysis of the haemostasis system of the patients with acute ischemic stroke as well as one year past acute phase of ischemic stroke were performed.
The significant inhibition of fibrinolytic potential of the post stroke patients were showed. The development of both pathological conditions accompanied by lengthening of time of the euhlobulin frsction lysis and FXIIa-dependent fibrinolysis. Moreover cardioembolic ischemic stroke were inherent more threatening performance. Lower activity of plasmonogen as well as α2-antiplasmin in blood plasma of the patients with atherothrombotic ischemic stroke was showed. Both tested pathological conditions were accompanied with abnormal concentrations of t-PA and PAI-1. Even one year past stroke attack the disorders in fibrinolysis still saved.

Key words: Ischemic stroke, PAI-1, t-PA, Plasminogen, α2-antiplasmin, FXII-dependent fibrinolysis, Euglobulin lysis time.

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