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EFFECTS OF AZELASTINE AND SODIUM CROMOGLYCATE IN THE INHIBITION OF BRONCHO - CONSTRICTION OF OVALBUMIN SENSITIZED LUNG PARENCHYMAL TISSUES OF GUINEA PIGS IN VITRO

Syed Saud Hasan, Aftab Turabi, Shaheen Sharaf Shah, Muhammad Yousuf Salat, Munawar Alam Ansari and Mehar Ali.

Abstract
OBJECTIVE: To see the ability of Azelastine and Sodium cromoglycate in influencing antigen
induced contractile responses in isolated parenchymal tissues of Guinea pig in vitro.
DESIGN: An experimental study.
SETTING: Department of Pharmacology and Therapeutics of Basic Medical Sciences Institute,
Jinnah Postgraduate Medical Center (JPMC), Karachi during 1998.
METHODS: The Guinea pigs (n=10) were sensitized with ovalbumin and their parenchymal strips
were exposed to different concentrations of ovalbumin to observe the EC50. Each sensitized
parenchymal strip was treated with either Azelastine or Sodium cromoglycte in an organ bath for
10 minutes and treated with EC50 ovalbumin and contraction was recorded by Grass Polygraph
model 7B.
RESULTS: EC50 (n=6) of parenchymal strips (0.3x10-6 + 0.16x10-6g/ml) produced a mean response
of contraction 9+0.44mm. Azelastine in concentration of 10-9 g/ml did not show any inhibitory
effect but as the concentration increased to 10-8 g/ml, marked inhibition was recorded and with
further increase in concentration by 10-7 g/ml, it completely antagonized the EC50 induced
contraction. Sodium cromoglycate did not show any inhibition at concentration 10-8 g/ml while at
higher concentration of 10-6 g/ml, it showed complete antagonism.
CONCLUSION: Ovalbumin induced contraction of sensitized lung parenchymal tissues of
Guinea pig in vitro is dose dependent and controlled better with Azelastine than Sodium
cromoglycate.






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