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Original Article

J Liaquat Uni Med Health Sci. 2007; 6(3): 127-129


SERUM LACTATE DEHYDROGENASE ISOENZYMES AS MARKER FOR LUNG TISSUE DAMAGE IN ACUTE BRONCHITIS PATIENTS

Abdul Shakoor Memon, Habibullah Qureshi, Muhammad Ali Memon, Badar-u-Din Memon and M. Saleh Memon.

Abstract
BACKGROUND/OBJECTIVES: Total serum lactate dehydrogenase (LDH) and LDH isoenzymes
are found increased in tissue damaging diseases. Literature reveals that LDH and its isoenzymes
specifically LDH-3 increase in blood due to damage of lung tissue. Acute bronchitis is
diagnosed only on clinical grounds and no laboratory tests had been established to confirm
diagnosis. This study was conducted to establish a guiding factor that can be helpful in assessment
of lung tissue damage and this finding will be having prognostic importance including
drug effectiveness in acute bronchitis patients which can be helpful in prevention of developing
the chronic course of illness.
METHODS: Patients were collected from Out Patients Department of Liaquat University Hospital
Jamshoro / Hyderabad, Sindh - Pakistan. Total serum LDH was estimated by spectrophotometer
and LDH isoenzymes were measured by electrophoresis on cellulose acetate membrane.
RESULTS: Total serum LDH (260.84±7.08mu/ml p

Key words: LDH isoenzymes. Acute bronchitis. Cellulose acetate electrophoresis.



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