OBJECTIVE: To see the effectiveness of Indomethacin in the passage of ureteric calculi in our set up. DESIGN: A descriptive study. PLACE AND DURATION OF STUDY: This study was conducted at Department of Surgery in collaboration with Department of Pharmacology at Liaquat University of Medical & Health Sciences, Jamshoro, Pakistan from January 1995 to December 2002. PATIENTS AND METHODS: This study was carried out on 150 patients with radio opaque ureteric stones having transverse diameter of 3 mm to 7 mm. Patients with severe hydronephrosis, congestive cardiac failure, peptic ulcer, gastritis, hepatorenal impairment, known hypersensitivity to NSAIDs, coagulation disorders were excluded. Children under 14 years of age, pregnant and lactating mothers were also excluded. A proforma with detail history and investigations related to renal functions was filled in every case. Intravenous infusion of indomethacin; 100 mg (2 ampules of Meglumine Indomethacinate) in 500 ml of 5% Dextrose water for a period of 2 hours once daily for 1 to 2 weeks was given to all these patients and the relief of pain and passage of ureteric calculi was monitored. RESULTS: One hundred and fifty patients including 120 males (80%) and 30 females (20%) with male female ratio (4:1) having mean age of 28.8 years were enrolled in this study. Highest presence of ureteric calculi was seen in 21-40 years. 143 patients (95.34%) passed stones within 1-4 weeks period, 7 patients (4.66%) did not pass stones. 132 patients (88%) had complete pain relief while 18 patients (12%) had partial pain relief and needed other drugs. CONCLUSION: NSAIDs especially indomethacin could well be tried in urinary calculi which are smaller in size before resorting to surgical measures.