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Original Article

J Liaquat Uni Med Health Sci. 2009; 8(3): 219-223

Ophthalmic Manifestations of Thyroid Orbitopathies

Rajesh Rathi, Maria Nazish.

OBJECTIVES: To describe age and sex specific rates of ocular/orbital involvement in thyrotoxic
patients, to determine the rates of all components of NOSPECS classification system in patients
with thyroid orbitopathies and to determine the relative magnitude of low and high index orbitopathies.
STUDY DESIGN: Prospective study.
METHODS AND MATERIALS: A total of 100 thyrotoxic patients of all age groups and both sexes
were examined at the Department of Ophthalmology, JPMC, Karachi.
RESULTS: Male to female ratio was1:2.5. Age range was12-80years. Mean age was 36.59+13.81.
The difference in age according to sex was found statistically non significant (P=0.60). Seventyfour
percent patients had some sort of orbitopathy. Lid sign happened to be the most persistent
sign of the orbitopathies (74%). The rates of the components of the NOSPECS classification
system were N=26%, O=56%, P=16%, E=11%, C=13%, S=7% respectively. Patients with low index
thyroid orbitopathy were 83% and 17% patients were with high index orbitopathy. High index
orbitopathy was found to be more common in the males with age above 40 years.
CONCLUSION: The occurrence of thyroid orbitopathy appears to be independent of age and
sex. Low index orbitopathies are more common than high index orbitopathies. Males are more
at risk of developing high index orbitopathy than females.

Key words: Thyroid Orbitopathies, thyrotoxic, NOSPECS.

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