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Original Article

J Liaquat Uni Med Health Sci. 2009; 8(2): 126-130

Detection of Helicobacter Pylori Antigen in Stool

Abdul Saleem Qadeer, Saleem Ahmed Kharal, Muhammad Farooq Baig, Jawed Ahmed Badvi and M. Asif Durrani.

OBJECTIVE: To detect H. Pylori antigen in stool and to determine the diagnostic accuracy of H.
pylori stool antigen.
DESIGN: Comparative analytical study.
SETTING: This study was carried out at Pakistan Medical Research Council (PMRC), at Jinnah
Postgraduate Medical Centre, Karachi from May 2006 to September 2006.
MATERIAL METHODS: Endoscopic biopsy specimens were collected for rapid urease test and
histopathology examination. Stool samples were taken for detection of antigen of Helicobacter
pylori. The stool antigen test is a rapid immuno-assay based on “lateral flow chromatography
technique” using monoclonal antibodies for qualitative detection of Helicobacter pylori antigen
in human stool.
RESULT: Fifty males and 50 females were selected for this study by non-probable purposive
sampling technique. Their mean age was 39 years ranging from 15 to 55 years. The sensitivity
and the specificity of Helicobacter pylori stool antigen test (HPSA) with rapid urease test was
found to be 89.1% and 92.6% respectively and the sensitivity and specificity of HPSA test with
histopathology was 92.8% and 89.6% respectively.
CONCLUSION: Helicobacter pylori stool antigen (HPSA) is an accurate easily carried out in routine
laboratory and is non-invasive.

Key words: Helicobacter pylori, sensitivity, specificity, rapid urease test, histopathology.

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