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Original Article

J Liaquat Uni Med Health Sci. 2009; 8(2): 100-105

Causes of Hypoglycemia in Diabetes Mellitus Patients

Muzaffar A. Shaikh, Mukhtiar Soomro, Nand Lal Rathi, Narinder Maheshwari and Darshana Kumari.

OBJECTIVE: To determine the causes of hypoglycemia in diabetics presenting at Liaquat University
Hospital Hyderabad/Jamshoro.
STUDY DESIGN: Descriptive observational study.
PLACE AND DURATION: Medical and Cardiology units of Liaquat University of Hospital Hyderabad
/Jamshoro, from June 2007 to May 2008.
PATIENTS AND METHODS: One-hundred and one hypoglycemic cases were analyzed. A detailed
enquiry about the presenting symptoms and mode of therapy was made. A thorough
physical examination to look for diabetic complications and any concurrent illness was performed.
Blood glucose was measured with the help of a Glucometer and response to glucose
administration was also noted. Data were computed using SPSS software version 14. P-value
up to 0.05 was considered significant.
RESULTS: Type-2 diabetics presented more commonly with hypoglycemia in adult diabetic
population 81/101 (80.1%). Mean age for type-1 diabetics was 27.7 years and for type-2 diabetics
53.6 years. Male to female ratio was 3.3:1. Type-1 diabetic patients were either brittle diabetics
with frequent dosage manipulations or those who had developed chronic complications. Majority
of type-2 diabetics 74/81 (91.4%) were more than 40 years of age. Diabetic nephropathy,
change in dose of hypoglycemic agents, missed meals, and use of concomitant medications
were important associations with hypoglycemia in type 2 diabetic patients. All type-1 diabetics
recovered completely after glucose administration. Amongst type 2 diabetics, 5 (6.41%) developed
permanent disability and 6 (7.69%) patients died.
CONCLUSION: The adult males having type 2 diabetes suffer more from this complication.
Recognition of different causes of hypoglycemia in diabetes patients and prompt treatment of
hypoglycemia is important to prevent complications. The reasons of developing hypoglycemia
most of the times were on patientís hand.

Key words: Hypoglycemia, Diabetes mellitus, Hemoglobin A1c, Plasma glucose level.

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