Abstract

Background: Chronic obstructive pulmonary disease (COPD) is a term for a group of diseases that affects lung.

Objective: Objective of our study was to evaluate paraoxonase-1 (PON1) activity, malonyldialdehyde (MDA) and lipid profile in COPD patients and healthy control.

Materials and Methods: Serum MDA and PON1 level were measured by Kei Satoh and arylesterase method, where lipid profile was determined by biochemistry fully autoanalyzer (CPC TurboChem 100).

Results: The mean level of (marker of oxidative stress malonyldialdehyde) MDA was profoundly higher in cases (P < 0.0001) as compared to control group. The antioxidant enzyme PON1 were lower (P < 0.0001) in cases than control. The mean levels of total cholesterol, triglyceride, low-density lipoprotein (LDL), very LDL were significantly higher in cases as compared to control group. The mean level of high-density lipoprotein was lower in COPD patients as compared to control group.

Conclusion: Our results concluded that the reduction in PON1 activity could reflect oxidative changes of enzyme free cysteine residues.

Key words: Malonyldialdehyde; Paraoxonase-1; Chronic Obstructive Pulmonary Disease; Lipid Profile; Oxidative Stress