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Original Research

Dusunen Adam. 2017; 30(2): 95-100


Thiol/disulphide homeostasis in men with heroin addiction

Vahap Ozan Kotan, Fatma Meric Yilmaz, Salim Neselioglu, Ozcan Erel, Ihsan Tuncer Okay, Serkan Kiral, Abdurrahim Bakirhan, Erol Goka.




Abstract

Objective: Heroin addicts have increased oxidative stress which can disturb thiol/disulfide (SH/SS) homeostasis, causing disulfide formation. No study has determined the serum thiol amount and blood disulfide amount in heroin addicts. The aim of the study was to investigate dynamic SH/SS homeostasis in heroin addicts.
Methods: Serum SH/SS statuses of 31 heroin addicts and 31 healthy controls were compared to determine the changes in SH/SS homeostasis in heroin addicts. Blood serum native thiol and total thiol (ToSH) levels were measured and the disulfide bond amount was calculated as the half value of the difference between native thiol and ToSH levels. For comparison t-test was used.
Results: SH and ToSH levels were significantly lower (p

Key words: Addiction, disulfide, heroin, oxidative stress, thiol






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