Home|Journals|Articles by Year Follow on Twitter

Directory for Medical Articles

Open Access

Original Article

JNBS. 2017; 4(1): 8-12

Recognition Memory Impairment and The Role of DMSO, ALA and Vitamin C During Traumatic Brain Injury in Albino Rats

Bulama Ibrahim, Lawan Suleiman Bilbis, Abdullahi Yahaya Abbas, Nasiru Suleiman, kassim Ibrahim.

Expression of cognitive and functional disorders is a common clinical development of traumatic brain injury (TBI) that is essentially determined by the site and severity of the insult. The present study sought to examine the effects of closed-head TBI on memory in albino rats, in order to further examine the potential efficacy of an acute antioxidants treatment with Dimethyl Sulfoxide (DMSO), Vitamin C and Alpha lipoic acid (ALA). The rat model of closed-head injury by weight drop method was applied on anesthetized rats. The treatment protocol included single oral administration of DMSO, Vitamin C and ALA in three different doses (22.5, 45 and 67.5 mg/kg) 1hr post-TBI. The Novel Object Recognition Test as well as the Modified Neurological severity score (mNSS) were employed to assess post-TBI memory and neurological function respectively. Our results revealed a recognition memory deficit that was significant 7 days after TBI up to 14 days post-TBI. Most importantly, DMSO, Vitamin C and ALA were able to attenuate the memory impairment by TBI. The mNSS of the treated groups decreased significantly than the non-treated group in the first and second week. Conclusively, the use of antioxidants can help in the management of TBI by reducing oxidative stress and improving cognitive function.

Key words: Traumatic Brain Injury, Impairment, Memory, Neurological severity score

Article Language: Turkish English

Similar Articles

Corrigendum to 'The circular RNA TLK1 exacerbates myocardial ischemia/reperfusion injury via targeting miR-214/RIPK1 through TNF signaling pathway' [Free Radic. Biol. Med. 155 (2020), 69-80].
Song YF, Zhao L, Wang BC, Sun JJ, Hu JL, Zhu XL, Zhao J, Zheng DK, Ge ZW
Free radical biology & medicine. 2021; ():

The study of Raddeanin A cerebrovascular endothelial cell trafficking through P-glycoprotein.
Wang YY, Jiang CF, Liu X, Li JN, Cai GZ, Gong JY
Biochemical and biophysical research communications. 2021; 559(): 222-229

Traumatic Brain Injury: Mechanistic Insight on Pathophysiology and Potential Therapeutic Targets.
Thapa K, Khan H, Singh TG, Kaur A
Journal of molecular neuroscience : MN. 2021; ():

Growing role of S100B protein as a putative therapeutic target for neurological -and nonneurological- disorders.
Michetti F, Di Sante G, Clementi ME, Sampaolese B, Casalbore P, Volonté C, Romano Spica V, Parnigotto PP, Di Liddo R, Amadio S, Ria F
Neuroscience and biobehavioral reviews. 2021; ():

Managing agitation during early recovery in adults with traumatic brain injury: an international survey.
Carrier SL, Hicks AJ, Ponsford J, McKay A
Annals of physical and rehabilitation medicine. 2021; (): 101532

Full-text options

Add your Article(s) to Indexes
• CiteIndex: Articles & Statistics

American Journal of Diagnostic Imaging


Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright © ScopeMed® Information Services.