Home|Journals|Articles by Year Follow on Twitter

Directory for Medical Articles
 

Open Access

Original Research

Egypt. J. Exp. Biol. (Bot.). 2016; 12(2): 267-274


ANTIMICROBIAL, ANTICOAGULATION, FIBRINOLYTIC AND PREBIOTIC ACTIVITIES OF EXOPOLYSACCHARIDE PRODUCED BY MARINE KLEBSIELLA SP.

El Essawy A. Kamal, Abu Shady H. Mohamed, Abu El Kher A. Mohsen, Helal M. Mahmoud.

Abstract
The authors previously, achieved a high yield of exopolysaccharide production from a marine Klebsiella sp. The aim of the present study is determination of this exopolysaccharide composition and evaluation of its biological activities. The monosaccharide moieties of this exopolysaccharide were determined by complete hydrolysis, qualitative and quantitative paper chromatography of the hydrolysis product. The monosaccharide composition of this exopolysaccharide was galactose 16%, fructose 20%, glucose 32%, fucose 22%, and uronic acid 10%. The biological activities of the native and modified sulfated bacterial exopolysaccharide were investigated. No anticoagulation or fibrinolytic activities were recorded for the sulfated exopolysaccharide, but the native form of exopolysaccharide showed both activities. The native exopolysaccharide also showed higher antibacterial activity against S. aureus and E. coli but both the native and sulfated form had no antifungal activity against Candida albicans. MIC of the native and sulfated exopolysaccharide that sustain the highest bacterial inhibition zone was 15 mg/dl. No prebiotic activities were recorded for both. In conclusion, this biopolymer has significant biological activities and it has two rare monosaccharide moieties with very significant value namely fucose and uronic acid that require further adaptation for practical and industrial application.

Key words: Antimicrobial, Biological activities, Exopolysaccharide, Klebsiella sp, Marine.



Similar Articles

Visible light photodegradation of 2,4-dichlorophenol using nanostructured NaBiS: Kinetics, cytotoxicity, antimicrobial and electrochemical studies of the photocatalyst.
Kumar VGD, Balaji KR, Viswanatha R, Ambika G, Roopa R, Basavaraja BM, Chennabasappa M, Kumar CRR, Chen Z, Bui XT, Santosh MS
Chemosphere. 2022; 287(Pt 2): 132174

In vitro and in silico anti-osteoporosis activities and underlying mechanisms of a fructan, ABW90-1, from Achyranthes bidentate.
Li T, Hou X, Huang Y, Wang C, Chen H, Yan C
Carbohydrate polymers. 2022; 276(): 118730

Selective detection of enrofloxacin in biological and environmental samples using a molecularly imprinted electrochemiluminescence sensor based on functionalized copper nanoclusters.
Wang D, Jiang S, Liang Y, Wang X, Zhuang X, Tian C, Luan F, Chen L
Talanta. 2022; 236(): 122835

The different activities of RNA G-quadruplex structures are controlled by flanking sequences.
Zheng AJ, Thermou A, Guixens Gallardo P, Malbert-Colas L, Daskalogianni C, Vaudiau N, Brohagen P, Granzhan A, Blondel M, Teulade-Fichou MP, Martins RP, Fahraeus R
Life science alliance. 2022; 5(2):

The unintended consequences of the pandemic on non-pandemic research activities.
Walker J, Brewster C, Fontinha R, Haak-Saheem W, Benigni S, Lamperti F, Ribaudo D
Research policy. 2022; 51(1): 104369


Full-text options


Latest Statistics about COVID-19
• pubstat.org


Add your Article(s) to Indexes
• citeindex.org






Covid-19 Trends and Statistics
ScopeMed.com
CiteIndex.org
CancerLine
FoodsLine
PhytoMedline
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.



ScopeMed Web Sites