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Original Research

RMJ. 2025; 50(4): 878-880


Effect of sodium valproate and levetiracetam monotherapy on vitamin D levels among young epileptic Pakistani adults

Hina Aslam, Aisha Qayyum, Imrana Maqsood, Muhammad Tahir, Iqra Athar, Amtul Hafeez.



Abstract
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Objective: To determine the effect of Sodium Valproate (VPA) and Levetiracetam (LEV) monotherapy on levels of 25-OH Cholecalciferol in young epileptic Pakistani adult patients.
Methodology: This cross-sectional study included 100 healthy and epileptic individuals aged between 15-24 years, with no sex predilection. All participants were divided into four groups I-IV (n=25 each); healthy control, diseased control, epileptic patients on VPA and LEV monotherapies, respectively. Serum 25-OH Cholecalciferol was measured. Data were analyzed at SPSS version 23.0. One-way ANOVA test was used to compare all groups.
Results: Mean serum levels of 25-OH Cholecalciferol were significantly lowered (p

Key words: Epilepsy, Idiopathic generalized, valproic acid, levetiracetam, vitamin D.





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