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Factors affecting smear conversion in tuberculosis management

Aylin Babalık, Şule Kızıltaş, Hülya Arda, Korkmaz Oruç, Gülgün Çetintaş, Haluk Celalettin Çalışır.

Setting: Inpatient clinic at Ministry of Health Sureyyapasa Chest Diseases and Thoracic Surgery Training and Research Hospital
Objective: To identify risk factors associated with persistent sputum positivity at the end of 2 months of direct observed treatment
Design: Retrospective cohort study concerning evaluation of medical records of 547 patients with smear positive tuberculosis treated at our clinic from January 2004 to December 2005
Results: Of 547 patients with AFB positive smears, late conversion occurred in 11.9% while early conversion in 88.1%. Males composed 54.7% of the population, 31.9% of the population was ≤25 years old, 37.5% had exposure to tobacco, 15.7% had any drug resistance, 8.9% had co-morbid diabetes mellitus and 16.0% had extensive radiologic involvement. Based on significant association between sputum smear conversion and smoking for more than 20 package/year (

Key words: : tuberculosis, sputum smear positivity; sputum conversion

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