Abstract

Objective: To design an in vivo care model via anthocyanins’ neuro-protective therapeutic potential.
Methodology: In this vivo experiment, 20 healthy male eight weeks old rats were selected, and five groups were formed. Group I was the physiological/non-induced rats, where four other groups (n=16) of various sizes were administered with intraperitoneal injections of propionic acid (250 mg/kg/day for 5 days). Group II (induced with propionic acid PPA), Groups III, IV, and V used anthocyanin at the concentrations of 100 mg/kg, 200 mg/kg, and 400 mg/kg, respectively a regular diet for a total of 4 weeks. ELISA detected neurotrophins levels with Statistical analysis of ANOVA (Post hoc Turkey test).
Results: The levels of brain-derived neurotrophic factor (BDNF) were observed in the Anthocyanin-treated groups (III, IV, and V) as compared with the group (II), inferring that Anthocyanin therapy can heal autism like symptoms. The levels of measured BDNF (ng/ml) were as follows: Group I (12.1 ± 0.5), II (4.1 ±0.5), III (9.1 ±0.5), IV (7.5 ±0.5), and V (9.7 ±0.5). To be specific, BDNF levels in Groups III, IV, and V were higher than in Group II (PPA-induced) (p

Key words: Anthocyanin, neurodegeneration, autism models.