Home|Journals Follow on Twitter| Subscribe to List

Directory for Medical Articles
 

Open Access

Original Article



Computational, structural and functional aspects of hypothetical protein of Aspergillus flavus Pheromone Receptor Pre-A (PRP-A)

Maneesh Kumar, Sindhuprava Rana, Harish Kumar, Pratik Kumar, Manas Ranjan Dikhit, Rani Mansuri, Jainendra Kumar, Ganesh Chandra Sahoo.

Abstract
Pheromone Receptor Pre-A (PRP-A) is a G Protein-coupled receptor (G-PCR protein with seven transmembrane helices) in Aspergillus flavus, a filamentous fungus known for their aflatoxin production, germination and quorum sensing. It causes aspergillosis in human beings and domestic animals. With an aim to find a better inhibitor against aflatoxin, the structure was engineered, designed, screening against various compound databases. The LibDock protein-ligand interaction of DSv3.5 study suggests that blasticidin S, Pipernonaline and Piperin, inhibit PRP-A protein with highest binding affinity. The amino acids frequently involved in binding with the ligand blasticidin S of O2 and H33 and H234 at Arg 400 and Tyr 394 respectively.

Key words: Aspergillus flavus Homology modeling gpr B Model Validation Discovery Studio 3.5



Share this Article


Advertisement
American Journal of Physiology, Biochemistry and Pharmacology

SUBMIT YOUR ARTICLE NOW


ScopeMed.com
BiblioMed Home
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.