Objective: To investigate the association of circulating levels of sex hormone binding globulin with type 2 diabetes mellitus.
Study Design: Case control study.
Place and Duration of Study: The study was conducted at the Department of Chemical Pathology, Army Medical College Rawalpindi.
Material and Methods: This study consisted of two groups; A and B. Group A consisted of type 2 diabetic patients and group B consisted of healthy controls. Each group comprised of 60 participants which were randomly selected from Endocrinology Department of Military Hospital (MH), Rawalpindi. Fasting blood samples of the participants were analyzed for serum sex hormone binding globulin (SHBG), fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c) and fasting insulin levels. The biochemical analysis was carried out at the Chemical Pathology Department, Army Medical College Rawalpindi. The data obtained were statistically analyzed with SPSS version 20.
Results: In this study, low levels of SHBG (39.53 ± 22.25 vs. 62.35 ± 32.52, p=
Keywords: Homeostatic model assessment-Insulin resistance, Insulin resistance, Sex hormone binding globulin, Type 2 diabetes mellitus.