Colon cancer is the third most common cancer worldwide. Conventional therapies have shown moderate efficacy with severe adverse effects, therefore there is an urgent need for safer alternatives. In this study, Cistanche tubulosa, local name Thanoon, was considered as a potential phytotherapeutic strategy because of its known high therapeutic potential in traditional medicine and wide abundance in the Middle East region. Bioactive compounds were extracted from powdered C. tubulosa and tested for their anticancer properties against four colon cancer cell lines including two derived from primary tumor (CaCo2 and HCT116) and two derived from metastatic site (LoVo and SW620). Effect of C. tubulosa on induction of apoptosis and cellular redox homeostasis were also investigated. C. tubulosa exhibited a concentration and time-dependent inhibition of proliferation of all tested cancer cell lines by more than 60% upon 72 hours treatment with 1 mg/mL of crude extract. Inhibition of proliferation was marked by induction of apoptosis, intracellular reactive oxygen species production and mitochondrial superoxides. This data suggest that C. tubulosa is a promising candidate for additive anti-colon cancer therapy. This is the first study showing anticancer bioactivity of C. Tubulosa against colon cancer cells.
Cistanche tubulosa, colon cancer, redox homeostasis, anticancer bioactivity
Emerging roles of NRBF2/PI3KC3 axis in maintaining homeostasis of brain and guts.
Wu MY, Cai CZ, Yang C, Yue Z, Chen Y, Bian ZX, Li M, Lu JH
Neural regeneration research. 2022; 17(2): 323-324
A sensitive electrochemiluminescence biosensor for assay of cancer biomarker (MMP-2) based on NGQDs-Ru@SiO2 luminophore.
Fan X, Wang S, Liu H, Li Z, Sun Q, Wang Y, Fan X
Talanta. 2022; 236(): 122830
Hypoxia and Proton microbeam: Role of Gap Junction Intercellular Communication in Inducing Bystander Responses on Human Lung Cancer Cells and Normal Cells.
Autsavapromporn N, Kobayashi A, Liu C, Jaikang C, Ahmad TAT, Oikawa M, Konishi T
Radiation research. 2022; ():
Lectin Affinity Chromatography for the Discovery of Novel Cancer Glycobiomarkers: A Case Study with PSA Glycoforms and Prostate Cancer.
Llop E, Peracaula R
Methods in molecular biology (Clifton, N.J.). 2022; 2370(): 301-313
3D and 4D Tumorigenesis Model for the Quantitative Analysis of Cancer Cell Behavior and Screening for Anticancer Drugs.
Wessels D, Lusche DF, Voss E, Soll DR
Methods in molecular biology (Clifton, N.J.). 2022; 2364(): 299-318