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Hematological, biochemical, and histopathological study of the plant extract of Terminalia chebula Reitz., Aloe vera Linn., and Tamarindus indica Linn. on animal model: A comparative study

Mohammad Daud Ali, Mohammad Arif Naseer, Mohammad Aamir Mirza, Md. Sarfaraz Alam.

Abstract
Background: Terminalia chebula Reitz., Aloe vera Linn., and Tamarindus indica Linn. are used in the treatment of different kinds of ailments. Their comparative toxicity profile is very important because all three drugs also affect on vital organ.

Aims and Objectives: The foremost objective of the current study was relative evaluation of acute and subacute toxicity of the plant extracts of T. chebula Reitz., A. vera L., and T. indica L. in rats.

Materials and Methods: Acute toxicity was conducted by the taking limit dose of 5000 mg/kg body weight. Utterance was completed and recorded for 24 h 1 time daily up to 14 days. Rats were supervised for mortality and behavioral changes 1 time daily throughout all days of study. Meant for subacute study, diverse group of animals was treated for all the three plant extracts at three distinct dose levels at 100, 200, and 400 mg/kg of freshly prepared extracts, respectively, every 24 h orally for 28 days. Control group only administered distilled water and normal feed. At the last moment of the study, biochemical parameters, hematological investigation, and histopathological examination of organs such as liver and kidney were examined. The relative analyses of histopathological investigation were done for all the three plant extracts in comparison to controls.

Results: Not at all significant different (P > 0.05) or histopathological changes were detected in terms of hematological, biochemical parameters, and histopathological changes with respect to the control. None of any mortality and behavioral changes were noted.

Conclusions: Overall, analysis of the results concluded that medium-term oral administration of all three plant extracts does not show toxicity for 28-day treatment.

Key words: Acute Toxicity; Subacute Toxicity, Terminalia chebula Reitz.; Aloe vera L., Tamarindus indica L.


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